Duration Of Action, Bioavailability And The Effect Of CBD


How long does CBD work in the body and what is the effect of CBD?

Because many people have a misunderstanding regarding how CBD works and what the effect of CBD truly is, I decided to elucidate some essential points today.

To begin with, let us make clear that unlike THC, CBD has no intoxicating effect. For several years, scientists have carried out diligent research to clarify the exact mode of action of CBD. The main effects in general and at a glance:

1- Pain-relieving
2- Anti-inflammatory
3- Anti-convulsive
4- Mood-enhancing
5- Nausea-reducing
6- Anxiety-relieving
7- Balancing the immune system

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These were the most important results at a glance. However, they are extremely individual and strongly dependent on the dosage and form of the CBD itself. This is what we are going to talk about in more detail:

We can look at the CBD effect at different levels

1- Practical questions about CBD effect: When? How fast? How long?

2- The biochemical CBD effect in the body

3- The reaction on symptoms of diseases

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Practical questions about CBD effect: When? How fast? How long?

CBD is available in retail primarily as oil or as a highly concentrated paste. You can also buy capsules with CBD oil.

For this purpose, producers extract CBD from the plant and mix it with oil, usually hemp oil. The extraction process determines whether natural plant active ingredients are preserved in the CBD.

It also stipulates the presence of pure cannabidiol. Secondary plant active ingredients enhance the effect of CBD through the so-called entourage effect.

Extraction with carbon dioxide ensures that in addition to the CBD, a certain proportion of CBDA is retained.

This is the acid form in which CBD occurs in the plant. For this method, the gas penetrates under pressure at relatively low temperatures of 86 to 176 ° Fahrenheit into stems, leaves and flowers of the plant.

There it releases the active ingredients, and the gas evaporates under normal pressure. CBD is left behind together with natural plant active ingredients.

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Bioavailability of CBD

Water runs most processes in the body. CBD, however, is difficult to dissolve into water. Therefore, the bioavailability of oil is only between 13 and 19 percent.

If you take CBD oil orally, for example in capsule form, the active ingredient also enters the liver via the intestine.

This is responsible for fat loss and dismantles part of CBD. It, furthermore, reduces the duration of efficacy and the concentration of active ingredients in the body.

You can bypass these factors by dripping CBD oil on the mucous membranes under the tongue (sublingually).

This way, the CBD quickly enters the bloodstream. Liposomal CBD is particularly suitable for this type of intake. For this purpose, CBD connects with micelles or liposomes.

These substances are small and correspond to the chemical form of a cell membrane. This allows them to penetrate directly into tissues and cells and release the CBD directly to the environment – without the detour through the digestive system. This increases bioavailability many times over.

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CBD: When does the effect occur?

How fast does CBD work? The answer to this question depends on the type of intake. The most effective CBD effect is in the mouth. If you drop liposomal CBD or CBD oil on to the mucous membranes under the tongue, you can feel a relief of your symptoms within a few minutes.

The guideline is a waiting time of 20 to 40 minutes. After dripping, do not drink for 15 minutes, so that the mucous membranes can optimally absorb the active ingredients.

However, if the CBD has to pass through the digestive tract during oral intake, the effect is delayed. In this case, you can notice the beneficial effects at the earliest after 1 hour. However, this period can also take up to 3 hours.

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How long does the CBD effect last?

How long does the reaction of CBD last? It would be nice if we could give clear timeframes for this. In each person, the metabolic processes work slightly differently.

This also applies to the endocannabinoid system. The duration of action of CBD depends on the extent to which this system is pronounced.

In addition, the liver influences the duration of action. If your liver works well, it can quickly inactivate the CBD. Within 2 to 3 days, the body completely dismantles the CBD. In addition, the amount taken also determines how long CBD works.

The duration of action varies strongly

You can assume that the relaxing, pain-relieving effect of CBD oil lasts for between 3 and 12 hours. It is best to experiment until you have found the ideal dosage. You should clearly feel the effect of CBD for several hours.

You can not only take CBD as an oil, but also use it as a cream on the skin or inhale CBD as an e-liquid in an evaporator.

For these different ways of consumption, the following average indicative times for the duration of action can be quantified:

CBD Oil: 6 to 8 hours
Cream: Up to 6 hours
Inhalation: about 4 hours

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How much CBD for a noticeable effect?

The question of dosage is just as difficult to answer as the duration of the effect. Scientists have not yet found a satisfactory answer.

Experts recommend that the level of the dosage be tested gradually. You will receive CBD oil and other preparations with different drug concentrations. Manufacturers typically specify how much CBD a drop contains.

Although no dangerous side effects of CBD are known to date, you should talk to your doctor before taking it. The side effects of CBD are low compared to drugs such as immunosuppressants and cortisone.

Most often, participants in scientific studies complain of fatigue, diarrhea as well as changes in body weight and appetite.

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Increase the dose slowly

As an introduction, a quantity of 0.5 to 20 milligrams of CBD is recommended daily. Three drops of 5 percent CBD oil will supply you with 15 milligrams.

This amount may already be sufficient to relieve sleep disturbances, headaches, stress and nausea. If no side effects are noticeable, you can increase the dose after a few days.

The maximum dosage is currently 800 milligrams per day. It is available to cancer patients, epileptics and people with other life-threatening diseases.

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Dosage for autoimmune diseases

For rheumatoid arthritis, multiple sclerosis and inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis, experts recommend a dosage of up to 100 milligrams daily.

This corresponds to three drops of CBD oil with an active ingredient content of 15 to 20 percent. If you tolerate CBD oil well, but the duration of action is short, you can also increase this dosage.

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Dear co-creators

This was the first part of our CBD posts that explain essential details, including the effect of CBD, and clarify any misunderstandings regarding the outstanding plant-based medicine and pain reliever.

You can find out more about CBD and its effects on illness symptoms, effects on the endocannabinoid system and other receptors, as well as about its additional benefits in the article linked below:

How CBD Oil Can Contribute To More Well-Being In Everyday Life

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